Is Anavar Liver Toxic? (Hepatotoxicity of Oxandrolone)

  • By: Dave Moffat
  • Date: November 30, 2023
Is Anavar Liver Toxic

Anavar, also called Oxandrolone, is a popular steroid with fewer side effects than others.

But it’s important to look closer at the possible dangers of using it, especially liver damage.

Anavar is a steroid that is modified to pass through the liver without breaking down.

However, this change can cause higher levels of liver enzymes. These enzymes, called ALT and AST, may show liver stress or damage.

Liver problems may not be obvious until the liver fails and becomes life-threatening.

This article explains the liver toxicity of Anavar using scientific research and clinical studies.

The Toxic Impact of Anavar on Your Liver

Anavar, or Oxandrolone, is a steroid used to grow muscles. Although it’s considered a less strong steroid, it can still harm your liver.

Potential Hepatic Dysfunction

Anavar may cause liver problems, like damage or disease that affects liver function. Liver enzyme levels can be mildly disrupted or lead to liver failure.

Liver Failure

In severe cases, Anavar use can lead to liver failure. This is a life-threatening condition where the liver stops functioning properly. The disease can cause skin and eye yellowing, belly pain, swelling, and confusion.

Liver Cysts and Tumors

Anavar use can also contribute to the development of liver cysts and tumors. Abnormal growths can be uncomfortable and cause serious complications if they rupture. It’s worth noting that while liver tumors can be benign (non-cancerous), they can also be malignant (cancerous).

Other Liver Problems

Beyond these serious conditions, Anavar use can also lead to other liver problems. It can change cholesterol levels. Good HDL cholesterol decreases and bad LDL cholesterol increases. This can contribute to the development of fatty liver disease and other liver problems.

Effects of Anavar on Liver and Kidneys

Anavar, also known as Oxandrolone, is an anabolic steroid that is often used by bodybuilders and athletes to gain muscle mass and strength. Anavar, like other steroids, can affect the liver and kidneys, among other organs.

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Effects on the Liver

Anavar is a steroid that has been changed to survive when taken by mouth and through the liver. This change makes the drug harder for the liver to break down, which could harm the liver.

According to a study in “Drug and Alcohol Dependence,” using anabolic steroids, such as Anavar, can cause liver problems. An article in the “Journal of the American Medical Association” mentioned hepatis, which are blood-filled liver cavities, in people who use anabolic steroids.

Effects on the Kidneys

The kidneys are also significantly affected by Anavar use. They play a key role in excreting the byproducts of steroid metabolism, and the increased workload can lead to kidney damage over time.

A study in the “Journal of Sports Sciences” found that six men had kidney problems from using anabolic steroids.” People on bodybuilding forums have shared stories that suggest Anavar use can affect kidney function.

Comparison with Other Steroids’ Liver Damage

Anavar seems to be safer for the liver compared to other steroids. Anavar is a type of steroid called Oxandrolone. It is known for being less harmful to the liver than other steroids. Anavar has less liver toxicity because it resists liver biotransformation. About 28% is excreted in urine.

However, other steroids can also harm the liver. A case study highlighted the manifestation of liver injury due to the off-label use of these steroids.

Further studies have shown liver damage in groups consuming certain anabolic steroids. For instance, Winstrol, another anabolic steroid, has been associated with liver damage.

However, while Anavar may be less toxic to the liver compared to some other steroids, it is not without risk. In rare cases, Anavar can cause serious liver problems that can be fatal. These problems include liver failure, liver cysts, and liver tumors. Thus, while Anavar may present a lower risk of liver toxicity relative to some other steroids, users should still exercise caution and consult with a healthcare professional before use.

Strategies for Liver Protection During a Steroid Cycle

Using steroids, especially oral ones like Anavar, can harm your liver. To protect the liver during a steroid cycle, it is very important to use strategies. Here are some of the most recommended practices:

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Medical Supervision

It is important to have a healthcare professional supervise steroid use. By doing this, we can catch and handle any possible side effects quickly and effectively.

Avoid Excessive Alcohol Consumption

Alcohol can put additional strain on your liver, so avoiding excessive consumption is crucial when on a steroid cycle.

Healthy Diet

Maintaining a healthy diet is also key. To keep your liver healthy, eat lots of fruits, veggies, lean proteins, and whole grains.

Non-Alkylated Steroids

Choosing non-alkylated steroids over alkylated ones can also help reduce liver stress. Alkylated steroids are harder on the liver as they have been chemically modified to survive liver metabolism.

Short Steroid Cycles

Shorter steroid cycles are generally safer than longer ones. Using steroids for longer periods of time can cause more liver damage.

Use of Supplements

Certain supplements, such as TUDCA, can reduce liver enzymes and support the regrowth of liver cells. Cholestyramine, a type of drug, can help by binding bile acids in the intestines. This prevents them from being absorbed again and eases strain on the liver.

HCG Diet

The use of an HCG (Human Chorionic Gonadotropin) diet has also been suggested. Pituitary gonadotropin plays an important role in the body and can support liver health.

Dave Moffat

Hi, I'm Dave Moffat the founder and Chief Editor of and certified International Personal Trainer and Certified Nutritionist. My passion has always been bodybuilding but with 15 years' experience in weight loss programs too, it's hard not to mention all that when you're working at your fitness level fullest (I hope). When Im not in the gym or spending time away from my family i often think about what advice would help others achieve theirs goals just like these inspired mine.