Ostarine (MK-2866) vs Ligandrol (LGD-4033): Which is more effective for muscle building?

  • By: Dave Moffat
  • Date: August 11, 2023
Ostarine (MK-2866) vs Ligandrol (LGD-4033)

Two popular SARMs, Ostarine and Ligandrol, have been found to have unique properties that set them apart from each other.

While both are effective in promoting muscle growth, they differ in terms of their anabolic-to-androgenic ratio, strength, potency, dosage, and suppression.

In this article, we will take a closer look at the similarities and differences between Ostarine and Ligandrol to help you make a more informed decision on which SARM is better suited for your needs.

What Is Ostarine (MK-2866)?

Ostarine, also known as MK-2866, is a selective androgen receptor modulator (SARM) that has become increasingly popular in recent years.

It has been extensively researched and is considered the most well-studied and mild SARM with a high safety profile.

Ostarine has been evaluated in numerous in vivo and in vitro studies, proving its efficacy in promoting fat and weight loss while preserving lean body mass.

Although it failed to receive FDA approval for lung cancer, it has the potential to be approved in the future with further research.

With high bioavailability and tolerability in humans, Ostarine can be taken in dosages of 0.1–100 mg per day.

Overall, Ostarine is a promising option for individuals looking to improve their body composition safely and effectively.

What Is Ligandrol (LGD-4033)?

Ligandrol (LGD-4033) is a popular compound among bodybuilders and athletes, thanks to its anabolic properties that make it easier to gain muscle mass.

Despite its effectiveness, there are concerns about its safety and potential side effects. However, research has shown that Ligandrol has a high safety profile in humans, even at dosages as high as 22 mg.

This is impressive, considering its anabolic: androgenic ratio is 500:1 in preclinical rat models, with RAD 140 enjoying a much lower ratio of 90:1.

It’s worth noting that Ligandrol is very suppressive and can cause heavy testosterone suppression with just 5 mg/day.

For those looking to bulk up, Ligandrol may be a desirable option as it offers a way to gain the muscle mass that’s difficult to replicate naturally.

Half-Life of Ostarine vs. Ligandrol

When it comes to choosing between Ostarine and Ligandrol, understanding the half-life of each is vital.

Ostarine has the advantage of being able to be safely used every day, as it does not accumulate in the body.

On the other hand, Ligandrol is much stronger than Ostarine, making it an attractive option for those looking to bulk up.

However, a study showed that blood serum levels of Ligandrol increased threefold in just three weeks.

While it has a purported half-life of 24 hours, this does not mean that it leaves the body quickly enough to make daily use advisable.

Ostarine VS Ligandrol – Benefits

As previously said, these two SARMs are utilized for various reasons, so it’s reasonable for one to dominate in some areas while falling short in others.

Muscle Mass

When it comes to building muscle, Ligandrol takes the lead as the more potent option compared to Ostarine.

Those who have tried Ligandrol have reported gaining an impressive 8 pounds of raw mass in just 8 weeks a feat that may take much longer with Ostarine’s reported 2-3 pounds of lean mass in 2 months.

While Ostarine may not be the best option for building mass, it does have a valuable use in preventing muscle wasting and loss during a cut.

With these options available, individuals looking to increase muscle mass can choose the best option that suits their specific goals.


Ligandrol, in particular, has proven to be a powerful ally in the quest for strength gains.

Users report increased strength and an intense pump, which can help to push through plateaus and take their training to the next level.

While other supplements like Ostarine may have some benefits, they simply don’t measure up when it comes to the incredible improvements in strength that can be seen with Ligandrol. 

Fat Loss

Ostarine has been shown to aid in fat loss, making it an attractive option for those looking to shed extra pounds.

However, it’s important to note that not all supplements are created equal. Contrary to Ostarine, Ligandrol has not demonstrated any weight loss effects and may even contribute to an increase in fat mass.


Ostarine is known to induce fat loss, which in turn leads to increased vascularity. Ligandrol, on the other hand, is a potent SARM that is also capable of promoting vascularity.

While Ostarine may take the lead in terms of its ability to boost vascularity, some users may prefer Ligandrol for its potential to enhance strength and power.

Energy and Stamina

For those looking to increase their energy and stamina, Ligandrol may be a viable option.

Scientific studies have shown that this chemical compound has the potential to significantly improve energy levels and athletic performance.

On the other hand, Ostarine does not appear to have any effect on energy levels.

Side Effects of Ostarine vs. Ligandrol

Some readers may have reached this point in the article believing that Ostarine is a sure loser and that there is no reason not to go on to Ligandrol. I hope that this section will persuade you that what goes up must come down.


When it comes to SARMs, suppression is a topic that cannot be ignored. Ligandrol, in particular, is known to be much more suppressive than any other SARM, even on a milligram-to-milligram basis.

The dosage matters too: as little as 2.5 mg per day can lead to suppression, while dosages of 10 or 20 mg can cause a complete shutdown in users.

This is not something to be taken lightly. If you’re just starting, it’s wise to go with a SARM that has less suppression, like Ostarine.

Water Retention

Water retention is a common concern for those taking Ligandrol, as it is more likely to cause this side effect than Ostarine.

However, it is interesting to note that the author did not experience any water retention with either of these supplements.

While avoiding water intake may seem like the logical solution to preventing water retention, drinking a lot of water is key to reducing the risk of water retention when taking Ligandrol.


When it comes to the relationship between SARMs usage and libido, it’s important to note that different substances can have different effects on the user.

While Ostarine usage is generally not associated with any notable changes to the user’s sex drive, Ligandrol usage has been linked to a decrease in sexual motivation and performance.

Many users report that this decrease is especially noticeable during the latter stages of the cycle. 


Lethargy is a concerning issue that can have a significant impact on an individual’s daily routine.

One user reported experiencing lethargy while taking Ligandrol, a drug meant to help with muscle growth.

Interestingly, their life remained quite similar both before and during the drug’s use, suggesting a possible correlation between Ligandrol and a mood change.

The user believes that the drug may have played a part in their decreased energy.

Ostarine VS Ligandrol – Results

When it comes to the comparison of Ostarine and Ligandrol, the results are quite distinct.

Ligandrol is undeniably a more powerful compound, providing users with the potential to gain up to 8 lbs of muscle in 8 weeks.

In contrast, Ostarine is known to be more effective in cutting down weight and fat, thus achieving that shredded physique desired by many.

It is important to note that Ligandrol does not only increase muscle mass but also boosts one’s strength, power, stamina, and motivation, which Ostarine lacks.

Both compounds possess unique attributes and serve different purposes for bodybuilders.

It’s crucial to understand their differences, weigh their benefits, and carefully assess which supplement suits one’s bodybuilding goals more effectively.

Ostarine VS Ligandrol – Pricing

When it comes to choosing between Ostarine and Ligandrol, pricing is a key factor to consider. For those on a budget, Ostarine is a more cost-effective option compared to Ligandrol.

However, recent lawsuits from Viking Therapeutics have forced some companies selling SARMs to abandon the name ‘Ligandrol’.

As a result, trusted sources such as Science.bio have stopped selling the product. While vendors may look for ways to get around this ban, it’s important to proceed with caution and only purchase from reputable sources.

Ultimately, it’s important to weigh the cost savings against potential risks before making a decision.


When it comes to selective androgen receptor modulators (SARMs), both Ligandrol and Ostarine have gained popularity for their respective purposes.

While Ligandrol is known to be a stronger SARM, Ostarine carries fewer risks. However, it is essential to prioritize safety when deciding which SARM to take.

It is crucial to consult with a healthcare professional before taking any supplement, especially when it comes to SARMs.

Both Ligandrol and Ostarine are potent compounds and require careful consideration before use.

Therefore, it is essential to weigh the benefits and risks of each substance thoroughly. Ultimately, one should proceed with caution and prioritize their health above all else.

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Hi, I'm Dave Moffat the founder and Chief Editor of steroidsourcetalk.com and certified International Personal Trainer and Certified Nutritionist. My passion has always been bodybuilding but with 15 years' experience in weight loss programs too, it's hard not to mention all that when you're working at your fitness level fullest (I hope). When Im not in the gym or spending time away from my family i often think about what advice would help others achieve theirs goals just like these inspired mine.