Ostarine (MK-2866) vs Ligandrol (LGD-4033): Which is more effective for muscle building?

  • By: Dave Moffat
  • Date: December 17, 2023
Ostarine (MK-2866) vs Ligandrol (LGD-4033)

Two popular substances, Ostarine and Ligandrol, are often used by people who want to build muscle. But they each have different special features.

Both can help you grow muscles. However, they’re different in how strong, powerful, and effective they are, how much you should take, and how they affect your body.

In this article, we’ll look more closely at what’s the same and what’s different between Ostarine and Ligandrol. This will help you figure out which one is better for what you need.

What Is Ostarine (MK-2866)?

Ostarine, also known as MK-2866, is a type of substance called a SARM that lots of people have started using in recent years.

It’s been studied a lot and is thought to be the safest and easiest to handle SARM out there.

Lots of tests have shown that Ostarine can help people lose fat and weight while keeping their muscles.

Even though it didn’t get approved by the FDA for treating lung cancer, there’s a chance it could be approved in the future with more research.

Ostarine is easy for our bodies to use and handle, and people can take anywhere from 0.1 to 100 mg per day.

All in all, Ostarine is a good choice for people who want to change their body shape in a safe and effective way.

What Is Ligandrol (LGD-4033)?

Ligandrol (LGD-4033) is a popular compound among bodybuilders and athletes. It has anabolic properties that make it easier to gain muscle mass.

Despite its effectiveness, there are concerns about its safety and potential side effects. However, research has shown that Ligandrol has a high safety profile in humans, even at dosages as high as 22 mg.

This is impressive, considering its anabolic: androgenic ratio is 500:1 in preclinical rat models, with RAD 140 enjoying a much lower ratio of 90:1.

It’s worth noting that Ligandrol is very suppressive and can cause heavy testosterone suppression with just 5 mg/day.

For those looking to bulk up, Ligandrol may be a desirable option as it offers a way to gain the muscle mass that’s difficult to replicate naturally.

Half-Life of Ostarine vs. Ligandrol

When it comes to choosing between Ostarine and Ligandrol, understanding the half-life of each is vital.

Ostarine has the advantage of being able to be safely used every day, as it does not accumulate in the body.

On the other hand, Ligandrol is much stronger than Ostarine, making it an attractive option for those looking to bulk up.

However, a study showed that blood serum levels of Ligandrol increased threefold in just three weeks.

While it has a purported half-life of 24 hours, this does not mean that it leaves the body quickly enough to make daily use advisable.

Ostarine VS Ligandrol – Benefits

As previously said, these two SARMs are used for various reasons. It’s reasonable for one to dominate in some areas while falling short in others.

Muscle Mass

If you want to build muscle, Ligandrol is often the stronger choice compared to Ostarine.

People who have used Ligandrol have said they gained a big 8 pounds of pure muscle in only 8 weeks. That’s something that might take a lot longer with Ostarine, which usually helps people gain 2-3 pounds of lean muscle in 2 months.

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Even though Ostarine might not be the best for building muscle, it is really good at stopping muscle loss when you’re trying to lose weight.

So, if you’re looking to get more muscles, you can choose the best option that matches your specific goals.


Ligandrol, in particular, has proven to be a powerful ally in the quest for strength gains.

Users report increased strength and an intense pump, which can help to push through plateaus and take their training to the next level.

Other supplements like Ostarine may have some benefits. However, they simply don’t measure up to the incredible strength improvements seen with Ligandrol. 

Fat Loss

Ostarine has been shown to aid in fat loss, making it an attractive option for those looking to shed extra pounds.

However, it’s important to note that not all supplements are created equal. Contrary to Ostarine, Ligandrol has not demonstrated any weight loss effects and may even contribute to an increase in fat mass.


Ostarine is known to induce fat loss, which in turn leads to increased vascularity. Ligandrol, on the other hand, is a potent SARM that is also capable of promoting vascularity.

Ostarine may take the lead in boosting vascularity. However, some users may prefer Ligandrol for its potential to enhance strength and power.

Energy and Stamina

For those looking to increase their energy and stamina, Ligandrol may be a viable option.

Scientific studies have shown that this chemical compound has the potential to significantly improve energy levels and athletic performance.

On the other hand, Ostarine does not appear to have any effect on energy levels.

Side Effects of Ostarine vs. Ligandrol

Some readers may have reached this point in the article believing that Ostarine is a sure loser and that there is no reason not to go on to Ligandrol. I hope that this section will persuade you that what goes up must come down.


When it comes to SARMs, suppression is a topic that cannot be ignored. Ligandrol, in particular, is known to be much more suppressive than any other SARM, even on a milligram-to-milligram basis.

The dosage matters too: as little as 2.5 mg per day can lead to suppression, while dosages of 10 or 20 mg can cause a complete shutdown in users.

This is not something to be taken lightly. If you’re just starting, it’s wise to go with a SARM that has less suppression, like Ostarine.

Water Retention

Water retention is a common concern for those taking Ligandrol, as it is more likely to cause this side effect than Ostarine.

However, it is interesting to note that the author did not experience any water retention with either of these supplements.

Avoiding water intake may seem like the logical solution to preventing water retention. However, drinking a lot of water is key to reducing the risk of water retention when taking Ligandrol.


When talking about how using SARMs can affect someone’s interest in romance, remember that different substances can affect people differently.

Usually, using Ostarine doesn’t really change a person’s romantic feelings or actions. But, using Ligandrol has been connected with less romantic interest and performance.

A lot of people have said that this decrease is especially easy to notice toward the end of the cycle.

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Lethargy is a concerning issue that can have a significant impact on an individual’s daily routine.

One user reported experiencing lethargy while taking Ligandrol, a drug meant to help with muscle growth.

Their life remained quite similar before and during the drug’s use. This suggests a possible correlation between Ligandrol and a mood change.

The user believes that the drug may have played a part in their decreased energy.

Ostarine VS Ligandrol – Results

When you compare Ostarine and Ligandrol, they’re really different.

Ligandrol is definitely stronger, and it can help people gain up to 8 lbs of muscle in just 8 weeks.

On the other hand, Ostarine is better at helping people lose weight and fat, which is great for getting that lean look many people want.

Remember: Ligandrol boosts muscle growth, strength, power, stamina, and motivation. Ostarine doesn’t do that.

Both of these things have their own special features and are used for different reasons by bodybuilders.

It’s important to know how they’re different. Think about their benefits. Decide carefully which one fits your bodybuilding goals best.

Ostarine VS Ligandrol – Pricing

When it comes to choosing between Ostarine and Ligandrol, pricing is a key factor to consider. For those on a budget, Ostarine is a more cost-effective option compared to Ligandrol.

Recent lawsuits from Viking Therapeutics have forced some companies to abandon the name ‘Ligandrol’ when selling SARMs.

As a result, trusted sources such as Science.bio have stopped selling the product. While vendors may look for ways to get around this ban, it’s important to proceed with caution and only purchase from reputable sources.

Ultimately, it’s important to weigh the cost savings against potential risks before making a decision.


Selective androgen receptor modulators (SARMs) are popular. Ligandrol and Ostarine each have their own uses.

While Ligandrol is known to be a stronger SARM, Ostarine carries fewer risks. However, it is essential to prioritize safety when deciding which SARM to take.

It is crucial to consult with a healthcare professional before taking any supplement, especially when it comes to SARMs.

Both Ligandrol and Ostarine are potent compounds and require careful consideration before use.

Therefore, it is essential to weigh the benefits and risks of each substance thoroughly. Ultimately, one should proceed with caution and prioritize their health above all else.

Dave Moffat

Hi, I'm Dave Moffat the founder and Chief Editor of steroidsourcetalk.com and certified International Personal Trainer and Certified Nutritionist. My passion has always been bodybuilding but with 15 years' experience in weight loss programs too, it's hard not to mention all that when you're working at your fitness level fullest (I hope). When Im not in the gym or spending time away from my family i often think about what advice would help others achieve theirs goals just like these inspired mine.